What is PDRN in skincare?
PDRN, short for polydeoxyribonucleotide, is made of DNA fragments that are usually sourced from salmon. It has become one of the most talked-about ingredients in Korean skincare, appearing in serums, creams, toner pads and masks.
Why it is popular
Korean brands use PDRN in formulas designed for skin that looks smoother, bouncier and more refreshed. It is often paired with hydrators like hyaluronic acid and collagen, and with niacinamide.
Topical skincare versus clinic treatments
PDRN is also used in professional treatments in Korea. A cream or serum you apply at home is a different experience, so think of PDRN skincare as part of a hydrating, consistent routine rather than a substitute for a clinic procedure.
How to use PDRN products
Use them in the usual order: toner pads after cleansing, serums after toner, and creams to finish. They layer easily with most routines.
PDRN products we carry
Medicube’s PDRN Pink line includes toner pads, a capsule cream, a milky toner, an eye cream and a lip sleeping mask. Anua’s PDRN Hyaluronic Acid Capsule 100 Serum pairs PDRN with several types of hyaluronic acid.
Questions people ask
What is PDRN?
Polydeoxyribonucleotide, DNA fragments usually sourced from salmon, used in Korean skincare for smoother, refreshed-looking skin.
Is PDRN vegan?
PDRN is typically derived from salmon, so most PDRN products are not vegan. Check each product’s ingredient list.
Where does PDRN go in my routine?
Wherever the product type goes: pads after cleansing, serums after toner, creams near the end.
Keep reading
- Korean skincare routine order, morning and night
- Toner, essence, serum, ampoule: what is the difference?
- What is glass skin?
General information, not medical advice. Patch test new products and ask a dermatologist about skin conditions. Updated 2026-11-02.
